The mechanism of topical glutaraldehyde anhidrosis was studied by use of the stripping method, analysis of single sweat gland function, methylene blue iontophoresis, and skin biopsy. The stripping of the horny layer with cellophane tape caused a considerable return of sweating. The recovered sweat gland, after stripping of the horny layer of the glutaraldehyde-treated skin, showed the same functional activity as to the sweat secretion and sodium reabsorption as the sweat gland of control skin. These data suggest that the anhidrotic effect of topical glutaraldehyde is due to poral closure.
Sato K, Dobson RL. Mechanism of the Antiperspirant Effect of Topical Glutaraldehyde. Arch Dermatol. 1969;100(5):564-569. doi:10.1001/archderm.1969.01610290048010