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December 1969

Generalized Spiny Hyperkeratosis, Universal Alopecia, and DeafnessA Previously Undescribed Syndrome

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine (Dr. Morris), and the Department of Dermatology, The Children's Hospital of Philadelphia (Dr. Koblenzer) Philadelphia. Dr. Ackerman is currently with the Department of Dermatology, Harvard Medical School, and the Massachusetts General Hospital.

Arch Dermatol. 1969;100(6):692-698. doi:10.1001/archderm.1969.01610300042006

A case with generalized hyperkeratosis, universal alopecia, and a bilateral sensorineural hearing deficit is presented. We believe that this child is unique and neither clinically nor histopathologically resembles any hitherto described syndrome.