Three patients with long-standing, severe, complicated diabetes mellitus developed skin changes of scleredema adultorum of Buschke. The scleredema showed no tendency to resolve. Acid mucopolysaccharides were demonstrated histochemically in the dermis. The possibility is discussed that there may be some association between diabetes mellitus and scleredema.
Cohn BA, Wheeler CE, Briggaman RA. Scleredema Adultorum of Buschke and Diabetes Mellitus. Arch Dermatol. 1970;101(1):27-35. doi:10.1001/archderm.1970.04000010029004