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January 1970

Acne VulgarisStudies in Pathogenesis: Triglyceride Hydrolysis by Corynebacterium acnes in Vitro

Author Affiliations

Portland, Ore

From the Department of Dermatology, University of Oregon Medical School, Portland, Ore. Dr. Kellum is currently with the Mason Clinic, Seattle.

Arch Dermatol. 1970;101(1):41-47. doi:10.1001/archderm.1970.04000010043006

Sixty-three strains of Corynebacterium acnes (C acnes) were incubated individually in vitro with three representative triglycerides. Consistent differences were found in their ability to hydrolyze these triglycerides. Seventy-five percent of strains of C acnes isolated from patients with acne vulgaris split C12 triglyceride (trilaurin), 56% hydrolyzed C16 triglyceride (tripalmitin), and 88% cleaved C18:1 triglyceride (triolein). In comparison, 42% of isolates of C acnes from patients without acne vulgaris hydrolyzed C12 triglyceride (trilaurin), 17% of C acnes strains split C16 triglyceride (tripalmitin), and 58% split C18:1 triglyceride (triolein). The differences were significant to the 2% confidence level.

The results suggest that distinctive strains of C acnes inhabit the sebaceous follicles of the Tetracycline hydrochloride (10μg/ml and 30μg/ ml) blocked the in vitro hydrolyzing activity of six strains of C acnes known to possess such splitting abilities.