A patient who developed Bowen's disease and invasive squamous-cell carcinoma of the epidermis within the limits of a congenital linear nevus is reported. Bowen's disease had been present for seven years; squamous-cell carcinoma was first noted after the carcinoma in situ had been treated with topically applied fluorouracil.
Swint RB, Klaus SN. Malignant Degeneration of an Epithelial Nevus. Arch Dermatol. 1970;101(1):56-58. doi:10.1001/archderm.1970.04000010058009