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Article
January 1970

LEOPARD SYNDROME

Author Affiliations

University Hospital Department of Dermatology Ann Arbor, Mich 48104

Arch Dermatol. 1970;101(1):119. doi:10.1001/archderm.1970.04000010121032
Abstract

To the Editor.—  Gorlin and his co-workers have extensively reviewed the multiple lentigines syndrome.1,2 The term "leopard," which is sometimes associated with the syndrome, is an acrostic each letter of which stands for an associated defect. We and others3 feel that the family recently reported by Capute et al4 is representative of this syndrome. Their patients had lentigines, neural deafness, and probable cardiac problems, the three most consistent defects usually found.Patients with the multiple lentigines syndrome would appear to be more numerous than at first suspected. In addition to the patients previously reported from Michigan,5 we have seen a second family, the proband of which is a 9-year-old-boy who has pulmonary stenosis (the most common cardiac abnormality), muscular subaortic stenosis, lentigines, and neural deafness. Other members of his family are less severely involved. We are impressed with the variability in number and severity of defects

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