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Some of the most pressing problems of the growing field of allergy are considered in great detail in vol 13 of Progress in Allergy. There are two chapters of particular interest to dermatologic immunologists. The first is by Vaz and Prouvost-Danon and considers the "Behavior of Mouse Mast Cells During Anaphylaxis." They review the available literature as well as their own studies and hypothesize that two or more reaginic antibodies bind to antigen. The cryatalligable (Fc) portion of these antibodies then binds to receptors on the cell membrane, leading to its alteration in an unknown fashion and resulting in the release of histamine or other vasoactive amines. The second chapter of particular interest is that by Roy Patterson and his discussion of "Laboratory Models of Reaginic Allergy." He considers the clinical and pathogenetic aspects of atopic disease in dogs and finds that the canine reaginic antibody is very similar to
Sams WM. Progress in Allergy. Arch Dermatol. 1970;101(1):128-129. doi:10.1001/archderm.1970.04000010130037