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February 1970

Disseminated Histoplasmosis Presenting as Exfoliative Erythroderma

Author Affiliations


From the Department of Dermatology, Wayne State University School of Medicine, Detroit General Hospital, Detroit, and the Veterans Administration Hospital, Allen Park, Mich.

Arch Dermatol. 1970;101(2):216-219. doi:10.1001/archderm.1970.04000020086013

An elderly man presented with a chronic exfoliative erythroderma of unknown etiology. Skin biopsy suggested mycosis fungoides. After mucous membrane and cutaneous ulcers developed, Histoplasma capsulatum was cultured from skin and bone marrow. It was also identified on histopathologic examination. We know of only two other similar cases reported in the literature and suggest that idiopathic or confusing cases of exfoliative erythroderma, with or without ulceration, be evaluated for histoplasmosis.