Nine patients with a familial type of diffuse hyperkeratosis of the palms and soles are reported. Skin biopsies (and, in one case, epidermal kinetic studies) showed the changes of epidermolytic hyperkeratosis. It is suggested that the category of epidermolytic hyperkeratosis be expanded to include this variety of keratoderma palmaris et plantaris.
Klaus S, Weinstein GD, Frost P. Localized Epidermolytic HyperkeratosisA Form of Keratoderma of the Palms and Soles. Arch Dermatol. 1970;101(3):272-275. doi:10.1001/archderm.1970.04000030016003