The clinical application of electron microscopy for the rapid diagnosis of viral infections is illustrated by two human and three bovine cases of milker's nodules. The virus was present in both crusts and biopsy material from quite different clinical lesions. A provisional diagnosis was available within one hour. Since preservatives or refrigeration are not necessary, crusts and dried vesicle fluid of suspected lesions of herpes or poxvirus infections can be mailed to a distant electron microscopic facility, providing a quick, practical method for the identification of distinct viral groups.
Davis CM, Musil G. Milker's NoduleA Clinical and Electron Microscopic Report. Arch Dermatol. 1970;101(3):305-311. doi:10.1001/archderm.1970.04000030049007