Six of seven patients with Raynaud's disease were subjectively benefited by the administration of "fine-particle" griseofulvin in dosages of 500 or 1,000 mg daily. Objective improvement was determined by measuring the digital temperature response following a one-minute exposure of the digit to stirred ice water maintained at 0 C. The temperature curves following griseofulvin therapy showed a much more rapid recovery toward normal when compared to the original baseline curves, and, in most instances, approached the mean control curve of 14 normal subjects.
Charles CR, Carmick ES. Skin Temperature Changes in Raynaud's Disease After Griseofulvin. Arch Dermatol. 1970;101(3):331-336. doi:10.1001/archderm.1970.04000030075012