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March 1970

Acne VulgarisStudies in Pathogenesis: Fatty Acids of Corynebacterium acnes

Author Affiliations

Seattle; Portland, Ore

From the Department of Dermatology, University of Oregon Medical School, Portland. Dr. Kellum is now in private practice in Seattle.

Arch Dermatol. 1970;101(3):337-339. doi:10.1001/archderm.1970.04000030081013

The fatty acids from 42 isolates of Corynebacterium acnes were studied by gas-liquid chromatography, and ranged from C10 to C18 with trace amounts of fatty acids above C18. The predominant fatty acid had a carbon number of 14.66, the relative carbon number of isobranched C15 fatty acid. No significant differences were found in the fatty acid pattern of the C acnes from patients with and without acne. We believe this excludes the alternative that irritant (medium chain length, eg, C8 to C14) fatty acids are derived from C acnes.