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March 1970


Author Affiliations

Department of Dermatology The Royal Infirmary Edinburgh, EH3 9YW Scotland

Arch Dermatol. 1970;101(3):369. doi:10.1001/archderm.1970.04000030113023

To the Editor.—  In the Archives of Dermatology (Sweat gland necrosis in barbiturate poisoning. 100:218-221 [Aug] 1969), I was interested in Dr. U. W. Leavell's article in which he describes sweat gland necrosis occurring in a biopsy taken from an erythematous area in a patient suffering from barbiturate intoxication. This prompted me to review some of the material which was collected during a study which I did.1It is well known that many patients suffering from barbiturate intoxication show an initial tendency to hypothermia which is followed by a period of hyperthermia, and in our experience normally lasts 24 to 48 hours. We did not find, however, that this particularly occurred in patients who developed bullae. While I would agree that the cause of these temperature changes is not understood and further investigation of sweat gland function in this condition would be of interest, I think one would

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