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April 1970

Association of Stomatitis and Paronychias Due to Herpes Simplex

Author Affiliations

Rochester, Minn

From the sections of dermatology (Dr. Muller) and microbiology (Dr. Herrmann), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Dermatol. 1970;101(4):396-402. doi:10.1001/archderm.1970.04000040018005

The simultaneous occurrence of stomatitis and paronychias of the fingernails due to the virus of herpes simplex was noted in two young women. The paronychial infections were most likely the result of auto-inoculation of virus by nail-biting. Herpes simplex virus was isolated in cell cultures of the oral and paronychial lesions, and complement-fixing and neutralizing antibody tests showed a fourfold or greater rise in titer during healing. Fifteen additional cases of the syndrome of concurrent stomatitis and paronychias due to herpes simplex virus have been reported in the literature. It is likely that oropharyngeal infection is more frequent in patients with herpetic paronychia and may pass unnoticed, unless the oral tissues are examined carefully or virus cultures of the saliva are done.