After two patients received both prednisone and methotrexate, an acute, florid eruption of hundreds of lesions of molluscum contagiosum developed. There is a heightened risk of viral infection in patients receiving immunosuppressive drugs.
Rosenberg EW, Yusk JW. Molluscum ContagiosumEruption Following Treatment With Prednisone and Methotrexate. Arch Dermatol. 1970;101(4):439-441. doi:10.1001/archderm.1970.04000040061012