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June 1970

Childhood Bullous Dermatitis HerpetiformisNegative Immunofluorescent Tests

Author Affiliations

Rochester, Minn; Minneapolis; Buffalo; Rochester, Minn

From the Mayo Graduate School of Medicine (University of Minnesota), Rochester (Dr. Jordon); Division of Dermatology, University of Minnesota, Minneapolis (Dr. Bean); Department of Microbiology, School of Medicine, State University of New York at Buffalo (Dr. Triftshauser); and Section of Dermatology, Mayo Clinic, Rochester, Minn (Dr. Winkelmann).

Arch Dermatol. 1970;101(6):629-634. doi:10.1001/archderm.1970.04000060001001

Indirect immunofluorescent (IF) staining revealed that the sera of six patients with active childhood bullous dermatitis herpetiformis (also referred to as childhood bullous pemphigoid) were negative for basement-membrane zone or "pemphigoid" antibodies. Direct IF studies of skin lesions from three of these patients also yielded normal results, in contrast to that noted in adult bullous pemphigoid. Bullous dermatitis herpetiformis or bullous pemphigoid of childhood, therefore, appears to be immunologically distinct from bullous pemphigoid as it occurs in the adult. "Benign chronic bullous dermatosis of childhood" may be a more appropriate name for this disease.