Certain dermatoses may be complicated by systemic amyloidosis. The underlying disorders in eight of 100 patients with secondary systemic amyloidosis studied at autopsy were: hidradenitis suppurativa, stasis ulcers, psoriatic arthritis, basal cell carcinoma, dystrophic epidermolysis bullosa, and lepromatous leprosy (three cases). When proteinuria or hepatomegaly is discovered in a patient with a potentially amyloidogenic dermatosis, the possibility that secondary systemic amyloidosis has developed should be considered.
Brownstein MH, Helwig EB. Systemic Amyloidosis Complicating Dermatoses. Arch Dermatol. 1970;102(1):1-7. doi:10.1001/archderm.1970.04000070003001