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July 1970

Uniovular Twins Discordant for Cutaneous Mastocytosis

Author Affiliations

New York; Albany, NY

From the Orentreich Foundation for the Advancement of Science, Dermatology Research Unit, New York (Drs. Selmanowitz and Orentreich), and Albany (NY) Medical College (Dr. Demis).

Arch Dermatol. 1970;102(1):34-41. doi:10.1001/archderm.1970.04000070036005

Urticaria pigmentosa occurred in only one member of a pair of uniovular twins observed at 22 years of age. The twin without skin lesions had neither clinical or roentgenologic evidence of systemic mastocytosis, nor elevation of 24-hour urinary excretion of free-histamine and mucopolysaccharides. Previous articles described six pairs of uniovular twins concordant for cutaneous mastocytosis and one pair of uniovular twins in addition to two pairs of fraternal twins discordant for this condition. Our patient with urticaria pigmentosa differed from the affected uniovular twins by later onset and persistence of lesions.