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August 1970

HydroxyureaA New Treatment for Psoriasis

Author Affiliations

Lexington, Ky

From the Division of Dermatology, Department of Medicine (Dr. Leavell), and the Division of Hematology and Oncology (Dr. Yarbro), University of Kentucky Medical Center, Lexington.

Arch Dermatol. 1970;102(2):144-150. doi:10.1001/archderm.1970.04000080016003

In a double-blind study, nine of ten cases of severe psoriasis demonstrated clinical and histopathologic response to hydroxyurea. No toxic reactions were noted. The drug may be less toxic than methotrexate and is efficacious in the management of psoriasis. A double-blind comparison of hydroxyurea and methotrexate is indicated to determine relative efficacy and toxicity.