In a double-blind study, nine of ten cases of severe psoriasis demonstrated clinical and histopathologic response to hydroxyurea. No toxic reactions were noted. The drug may be less toxic than methotrexate and is efficacious in the management of psoriasis. A double-blind comparison of hydroxyurea and methotrexate is indicated to determine relative efficacy and toxicity.
Leavell UW, Yarbro JW. HydroxyureaA New Treatment for Psoriasis. Arch Dermatol. 1970;102(2):144-150. doi:10.1001/archderm.1970.04000080016003