The initiation and course of a chronic blistering disease and immunologic changes characteristic of bullous pemphigoid in an 11-year-old boy suggested that an allergic reaction to one or more drugs was followed by the development of antibodies with reactivity to the dermal-epidermal junction. The prolonged nature of the disease is hypothesized to be secondary to the presence of such antibodies.
Bean SF, Good RA, Windhorst DB. Bullous Pemphigoid in an 11-Year-Old Boy. Arch Dermatol. 1970;102(2):205-208. doi:10.1001/archderm.1970.04000080077015