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To the Editor.—
In the March 1970 issue of the Archives (101:340-347) Reed and Leone presented the thesis that porokeratosis of Mibelli is of the same general order as epithelial nevi and is a clonal disease of the epidermis much like actinic keratosis. I wish to compliment the authors on their thorough study and to concur with their well-documented biologic interpretation of this puzzling disease. Their data and conclusions come close to a hypothesis which I proposed in discussing Saunders' paper on porokeratosis (Arch Derm84:980-988, 1961). At that time I postulated on the basis of a much smaller material that porokeratosis "is a disc of permanently altered epidermis with a continuous active border and persistent active foci nearer the center" and that the basic change is one of benign neoplasia. Inasmuch as Saunders had stressed the histochemical similarities between the cornoid lamella and the epidermal-eccrine-sweat-duct-unit, I accepted
Pinkus H. POROKERATOSIS. Arch Dermatol. 1970;102(2):235-236. doi:10.1001/archderm.1970.04000080107029