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October 1970

Pilosebaceous Abnormalities in Apert's Syndrome

Author Affiliations


From the Department of Dermatology, College of Medicine (Drs. Solomon and Fretzin), and the Center for Craniofacial Anomalies (Drs. Solomon and Pruzansky), University of Illinois Medical Center, Chicago.

Arch Dermatol. 1970;102(4):381-385. doi:10.1001/archderm.1970.04000100029007

The clinical findings in nine patients with Apert's syndrome (acrocephalosyndactyly) revealed seven postpuberal patients to have widespread moderate-to-severe acne vulgaris on the face, chest, back, and in an unusual manner, the forearms. Since forearm acne is rare, the frequency of this finding without additional evidence of virilization in a group of patients with Apert's syndrome suggested they may have an abnormality of end-organ androgen disposition.