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October 1970

Eczema Vaccinatum in Darier's Disease

Author Affiliations

Stanford, Calif; St. Louis

From the departments of dermatology and pathology, University of Missouri Medical Center, Columbia.

Arch Dermatol. 1970;102(4):451-456. doi:10.1001/archderm.1970.04000100099021

A vaccinia virus infection that initially mimicked pyoderma proved life-threatening to a patient with Darier's disease (keratosis follicularis). Recognition of intracytoplasmic inclusions in touch preparations made from biopsied skin supported the suspected diagnosis of vaccinia virus infection and led to treatment with vaccinia immune globulin. The diagnosis of eczema vaccinatum was proved first through visualization of the virus by electron microscopy and later by rising antibody titers.