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December 1970

Story of the PitsA Historic Vignette

Author Affiliations


From the Department of Dermatology, University of Texas Southwestern Medical School, Dallas (Dr. Howell), and the Department of Dermatology, Wayne State University, Detroit (Dr. Mehregan).

Arch Dermatol. 1970;102(6):583-585. doi:10.1001/archderm.1970.04000120001001

Historic milestones in the story of the pits of the nevoid basal cell carcinoma (NBCC) syndrome include the observations and contributions of Pollitzer, Calnan, and Bettley, and Ward. Placing the pits as a stigma of the NBCC syndrome was sparked by the demonstration of jaw cysts and skeletal defects of development in Ward's patients, who in addition had multiple basal cell carcinomas and pits in the hands and feet. Subsequent studies of families or groups of individuals or both with this syndrome documented the pits as a sign of significant importance.