The clinical features of eight female patients with the oral-facial-digital (OFD) syndrome, including a description of the skin and its histological and pharmacological characteristics are described. The OFD syndrome is characterized in part by a cutaneous dyplasia which includes a marked diminution in sebaceous glands, some decrease in hair follicles, and early keratinous cyst formation, which may represent maldevelopment of the pilosebaceous unit.
Solomon LM, Fretzin D, Pruzansky S. Pilosebaceous Dysplasia in the Oral-Facial-Digital Syndrome. Arch Dermatol. 1970;102(6):598-602. doi:10.1001/archderm.1970.04000120016003