To the Editor.—
In their review of drug reactions to the sulfones, Millikan and Harrell commented that they were not aware of fatalities from agranulocytosis induced by sulfones.1A recent report from Vietnam,2 where Dapsone was used as daily prophylaxis against falciparum malaria, cited 16 cases of Dapsone-induced agranulocytosis of which eight patients died. As it was estimated that well over 100,000 troops were taking the Dapsone daily, the incidence of fatalities from agranulocytosis was, of course, very low. Nonetheless, as a result of severe side effects from Dapsone, it is no longer being used routinely for falciparum malaria prophylaxis in Vietnam.
Bernstein G. SULFONES. Arch Dermatol. 1970;102(6):694. doi:10.1001/archderm.1970.04000120112024