Cutaneous reactions to mafenide acetate (Sulfamylon Cream) occurred in three adults. All had a strongly positive patch test to the mafenide acetate. We believe the critical antigenic site of the mafenide molecule is the methyl group in the para position.
Velasco JE, Africk JA. Contact Dermatitis to Mafenide Acetate. Arch Dermatol. 1971;103(1):61-63. doi:10.1001/archderm.1971.04000130063009