Allergic contact dermatitis to the rubber antioxidant N-isopropyl-N-phenylparaphenylenediamine (IPPD) occurred in a patient. His vesicular dermatitis of the hands occurred with each washing of his Volkswagen. With automation, allergic contact dermatitis to IPPD has not been a problem to tire factory workers, but can be a problem to consumers using these rubber products.
Jordan WP. Contact Dermatitis From N-Isopropyl-N-Phenylparaphenylenediamine"Volkswagen Dermatitis". Arch Dermatol. 1971;103(1):85-87. doi:10.1001/archderm.1971.04000130087014