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February 1971

Severe Pneumonitis Occurring During Methotrexate TherapyReport of Two Cases

Author Affiliations


From the Department of Allergy and Dermatology, Lahey Clinic Foundation, Boston. Dr. Goldman is now at the US Army Hospital, Fort Leonard Wood, Mo.

Arch Dermatol. 1971;103(2):194-197. doi:10.1001/archderm.1971.04000140080014

Two patients with serious skin diseases were treated with intermittent, intramuscularly administered methotrexate in doses of 50 to 75 mg. Fever, cough, dyspnea, and bilateral noninfectious pulmonary infiltrates developed in both patients after several weeks of therapy. The respiratory illness were attributed to a pulmonary reaction, possibly allergic in nature, produced by methotrexate. Previous instances of pulmonary infiltrates secondary to methotrexate have been reported only in leukemic patients receiving intermittent therapy.