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Article
March 1971

Streptococcal EcthymaTreatment With Benzathine Pencillin G

Author Affiliations

Miami, Fla; USA; Washington, DC

From the University of Miami School of Medicine, Miami, Fla (Drs. Kelly and Taplin), and the Walter Reed Army Institute of Research, Washington, DC (MAJ Allen).

Arch Dermatol. 1971;103(3):306-310. doi:10.1001/archderm.1971.04000150076011
Abstract

Initial skin cultures yielded 100% recovery of group A streptococci from the lesions of 66 patients suffering from ecthymatous impetigo. Of the 66 patients, 85% also had coagulase-positive staphylococci in their lesions with 45% of the staphylococci resistant to penicillin G.

Patients were divided into two treatment groups. The first treatment group (30 patients) received 600,000 units of benzathine penicillin G intramuscularly in a single injection; whereas the second treatment group (36 patients) received 600,000 units of procaine penicillin G intramuscularly in a single injection. All patients receiving benzathine penicillin G showed complete healing within a week, whereas only 38% receiving procaine penicillin G healed within two weeks.

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