To the Editor.—
The case of a man who was resistant to fluorouracil applied topically even when fortified by purposeful exposure to direct sunshine was reported in 1969.1 This is to report that he responded with a normal inflammatory reaction and therapeutic result in 1970 to 5% fluorouracil solution (Efudex).
Epstein E. RESISTANCE TO FLUOROURACIL. Arch Dermatol. 1971;103(3):342. doi:10.1001/archderm.1971.04000150112025