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To the Editor.—
A recent review article in the Archives, "Drug Reactions to the Sulfones" (102:220-223, 1970), contains an error. The authors refer to the "two free amide groups" and "substitution on the amide groups" of diaminodyphenyl sulfone. An amide group is a derivative of ammonia that is formed by substituting an acyl group for an ammonia hydrogen; for example, the peptide bond contains an amide group. The nitrogen groups on diaminodyphenyl sulfone are primary amines and not amides.
Penneys NS. DRUG REACTIONS TO THE SULFONES. Arch Dermatol. 1971;103(3):343. doi:10.1001/archderm.1971.04000150113027