Cheilitis glandularis occurred in a Negro man and his two children. This seldom-recognized entity consists of an everted hypertrophic lower lip associated with enlarged labial mucous glands or dilatation of secretory ducts or both. Two of these patients also had mucous cysts (mucoceles) of the lip due to rupture of a duct. Histologic studies revealed a prominent hyperplasia of the mucous glands, variable amounts of chronic inflammation, and markedly dilated ducts containing mucin and cells. The familial occurrence of the disease suggests an hereditary factor which appears to be an autosomal dominant type. Surgical excision of the involved lower lip gave excellent results in the father. In whites, cheilitis glandularis is associated with a relatively high incidence of squamous cell carcinoma of the lower lip.
Weir TW, Johnson WC. Cheilitis Glandularis. Arch Dermatol. 1971;103(4):433-437. doi:10.1001/archderm.1971.04000160083013