Generalized acrodermatitis perstans occurred in a 50-year-old man. Lesions clinically and histologically characteristic of the disease could be produced by intradermal injection of monilial antigen. Generalization appeared to follow the administration of nystatin.
Petrozzi JW, Witkowski JA. Acrodermatitis PerstansGeneralization Following Therapy With Nystatin. Arch Dermatol. 1971;103(4):442-447. doi:10.1001/archderm.1971.04000160092015