Sebum secretion was measured by a quantitative gravimetric method in nine patients with Parkinson's syndrome. The patients were tested before and at intervals after the administration of levodopa (L-DOPA). A striking reduction in sebum secretion occurred in four patients, and one had a less dramatic decrease. The results of this study suggest a new approach in the search for therapeutically useful agents for the treatment of seborrhea and acne.
Harville DD, Appenzeller O. A New Approach to the Reduction of Sebum Secretion. Arch Dermatol. 1971;103(5):492-493. doi:10.1001/archderm.1971.04000170026005