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Article
July 1971

Ichthyosiform Erythroderma, Hair Shaft Abnormalities, and Mental and Growth RetardationA New Recessive Disorder

Author Affiliations

Singapore

From the Skin Clinic, Medical Unit II, University of Singapore.

Arch Dermatol. 1971;104(1):4-13. doi:10.1001/archderm.1971.04000190006002
Abstract

A new autosomal recessive disorder characterized by growth retardation, progeria-like appearance, mental deficiency, nonbullous congenital ichthyosiform erythroderma, and hair shaft defects consisting of pili torti and trichorrhexis nodosa-like lesions was found in three children of a Chinese family in Singapore. It is possible that this disease is closely related to other rare ectomesodermal disorders with congenital ichthyosis, hair shaft defects, and other congenital abnormalities, and a new classification of these conditions is therefore proposed.

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