We found a heterogeneous group of systemic diseases (15 to 26 cases) associated with necrotizing angiitis. Patterns of dermal vessel immunofluorescence were related to specific clinical and histopathologic lesions in 15 of 26 cases of necrotizing angiitis, in 4 cases of livedo vasculitis, and in 3 cases of facial granuloma. The immunoglobulins and complement staining were related to the distribution of histologic changes but not to the severity of such changes. Staining of β1-C/β1-A globulin in diseased dermal vessels superimposed IgG and IgM in seven of 15 biopsies. One or more serum immunoglobulins were altered (± 2 SD) in 15 of 22 patients with necrotizing angiitis. Globulins in perivascular spaces occurred more frequently in association with elevated serum immunoglobulins.
Schroeter AL, Copeman PWM, Jordon RE, Sams WM, Winkelmann RK. Immunofluorescence of Cutaneous Vasculitis Associated With Systemic Disease. Arch Dermatol. 1971;104(3):254-259. doi:10.1001/archderm.1971.04000210028005