The addition of 10% urea by weight to a commercially available steroid cream gave better results in the treatment of subacute and chronic atopic eczema than the steroid cream alone. Ten percent urea alone in a cream base will control the icthyotic stage of atopic eczema. Urea was found to be too irritant to apply to acute exudative eczema lesions. One case of congenital tylosis was considerably improved with the 10% urea cream.
Hindson TC. Urea in the Topical Treatment of Atopic Eczema. Arch Dermatol. 1971;104(3):284-285. doi:10.1001/archderm.1971.04000210058010