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September 1971

Allergic Contact Dermatitis Due to Ingredients of VehiclesA "Vehicle Tray" for Patch Testing

Author Affiliations

New York

From the Department of Dermatology, New York University School of Medicine.

Arch Dermatol. 1971;104(3):286-290. doi:10.1001/archderm.1971.04000210060011

One hundred patients suspected of having allergic eczematous contact dermatitis due to topically administered medications were patch tested with a "vehicle tray" composed of 15 substances commonly found in vehicles of current preparations. Positive tests were obtained in 30 of 100 patients. There were 18 reactions to ethylenediamine; 6 to lanolin; 3 to parabens; 2 each to phenylmercuric acetate, thimerosal, dichlorophene, propylene glycol monostearate, and triethanolamine; 1 to sorbic acid for a total of 40 positive reactions. Vehicles play a significant role in producing sensitization and allergic contact dermatitis. The importance of testing with a standard concentration of each ingredient in preference to the total formulation is shown by the sizable incidence of false-negative reactions with the total formulation.