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This is a most unusual book incorporating numerous observations which have not heretofore been published together. By reading this book, one can readily recognize why it is easily possible to have an experiment fail, not because the general experimental design was poor, but because the vagaries for eliciting the reaction are not understood. For instance, these authors demonstrate that the best age of guinea pigs for eliciting contact allergic reactions is 1 to 3 months, that males and females are equal in their potential, that pregnancy decreases the sensitization index, that sensitization may be elicited with equal readiness in both winter and summer, and that ambient temperatures have no effect. They also clearly demonstrate that the best area for sensitization is the scapular and that the use of other areas is considerably less effective. They also study the influence of the concentration and frequency of application on the topical sensitization
Sams WM. Allergic Contact Dermatitis in the Guinea Pig. Arch Dermatol. 1971;104(3):342. doi:10.1001/archderm.1971.04000210116030