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October 1971


Author Affiliations

Department of Dermatology Springfield Clinic Springfield, Ill 62703

Arch Dermatol. 1971;104(4):437. doi:10.1001/archderm.1971.04000220095024

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To the Editor.—  Since publication of my case report "Allergic Contact Dermatitis From Nystatin" (Arch Derm102:216-217, 1970), additional patch testing has been done on the patient, and I should like to add some follow-up observations.Various concentrations of nystatin in 10% propylene glycol were applied as occlusive patch tests to the upper part of the back and produced 3+ reactions at concentrations as low as 5,000μ/ml (1/20 the usual therapeutic concentration). Nystatin, 100,000μ/ gm in petrolatum produced a 4+ reaction, but with 50,000μ/gm and lower, no reaction occurred. Mycostatin ointment and Mycolog ointment caused 4+ reactions. All of these positive patch tests occurred at 96 hours but not at 48 hours following application of the patch test materials.Of the patch test vehicles mentioned here (propylene glycol and petrolatum) and in the original case report (ethyl alcohol), propylene glycol appeared to provide the best system for detecting nystatin

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