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Article
November 1971

RELATIONSHIPS OF MICROORGANISMS TO PSORIASIS—TOXIC OR ALLERGIC?

Author Affiliations

Department of Dermatology Boston University School of Medicine

Arch Dermatol. 1971;104(5):560-562. doi:10.1001/archderm.1971.04000230102019
Abstract

To the Editor.—  I was intrigued by the case report of Petrozzi and Witkowski entitled "Acrodermatitis Perstans" in which the authors present a case similar to generalized pustular psoriasis from which they isolated Candida albicans.1The eruption flared three times when treated with nystatin and was simulated by intradermal injection of oidiomycin but not with other bacterial or fungal antigens.Microorganisms, especially streptococci, have been incriminated in the genesis of various types of psoriasis. Candida recurs repeatedly on the pathogenetic scene, again recently in connection with "napkin psoriasis."Ferguson et al2 isolated C albicans from the skin of 48% of the napkin areas of patients with skin lesions. Intracutaneous tests with candidal extract were positive. They interpreted associated secondary lesions as "psoriasis like Ide" occurring in babies of a seborrheic habitus. In only five of 52 in Ferguson's cases and three of 28 in Warin's series3 did

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