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To the Editor.—
In the article "Fixed Eruption Due to Glutethimide" by Fisher and Lerman in the Archives (104:87, 1971) the statement is made that,The patch test at the fixed eruption site was positive to pure glutethimide, thereby eliminating the possibility of a fixed eruption due to any of a number of excipients used in the manufacture of Doriden tablets.However, it should be pointed out that an occlusive test at the site of a fixed drug eruption, or indeed of any eruption, remains "irritable" for several weeks and will often react in a nonspecific manner to any powder applied under an occlusive patch. Only if the pure glutethimide powder produced a reaction and a powder without this drug produced no reaction could one imply that a specific reaction was obtained.
Fisher AA. FIXED ERUPTION DUE TO GLUTETHIMIDE. Arch Dermatol. 1971;104(6):687. doi:10.1001/archderm.1971.04000240111020