During the last decade, the diverse use of quaternary ammonium compounds has greatly increased. Though quaternary ammonium compounds have been generally considered an unlikely allergen in the development of contact dermatitis, they do have a potential to induce sensitivity, particularly in damaged skin. This report describes a patient with a history of persistent nummular eczema, who developed an axillary dermatitis which was traced to a quaternary ammonium compound contained in his roll-on deodorant.
Shmunes E, Levy EJ. Quaternary Ammonium Compound Contact Dermatitis From a Deodorant. Arch Dermatol. 1972;105(1):91-93. doi:10.1001/archderm.1972.01620040059014