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January 1972

Effect of Hydroxyurea and Cytarabine on Rodent Epidermal Cells

Arch Dermatol. 1972;105(1):129. doi:10.1001/archderm.1972.01620040089029

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To the Editor.—  In regard to the excellent article by Dr. Stoughton, "Effect of Hydroxyurea and Cytarabine on Rodent Epidermal cells" (104:161-165, 1971), I would like to add that cytarabine has been used in at least two patients with severe psoriasis. Within the last year I have treated these two patients as follows.

Report of Cases 

Case 1.—  A 56-year-old white man had had psoriasis for 25 years. He had never been treated with methotrexate but had recently received systemic steroids, the withdrawal of which led to a severe flare. It was at that time that we saw him and admitted him to the hospital. Treatment was started with cytarabine, 2 mg/kg, which amounted to 120 mg by rapid intravenous injection once a day. At the end of seven days he was severely nauseated and there was no improvement in the psoriasis. Serial white blood cell counts

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