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To the Editor.—
In regard to the excellent article by Dr. Stoughton, "Effect of Hydroxyurea and Cytarabine on Rodent Epidermal cells" (104:161-165, 1971), I would like to add that cytarabine has been used in at least two patients with severe psoriasis. Within the last year I have treated these two patients as follows.
Report of Cases
A 56-year-old white man had had psoriasis for 25 years. He had never been treated with methotrexate but had recently received systemic steroids, the withdrawal of which led to a severe flare. It was at that time that we saw him and admitted him to the hospital. Treatment was started with cytarabine, 2 mg/kg, which amounted to 120 mg by rapid intravenous injection once a day. At the end of seven days he was severely nauseated and there was no improvement in the psoriasis. Serial white blood cell counts
Auerbach R. Effect of Hydroxyurea and Cytarabine on Rodent Epidermal Cells. Arch Dermatol. 1972;105(1):129. doi:10.1001/archderm.1972.01620040089029