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February 1972

Ultrastructural Study of a Case of Extramammary Paget's Disease of the Vulva

Author Affiliations

Hines, Ill, and Chicago

From the Dermatology Section Research and Education Service, Veterans Administration Hospital, Hines, Ill; and the Department of Dermatology, Abraham Lincoln School of Medicine, University of Illinois, Chicago.

Arch Dermatol. 1972;105(2):236-243. doi:10.1001/archderm.1972.01620050046010

Extramammary Paget's disease of the vulva was found in a 75-year-old woman. The ultrastructural features of Paget cells include rare desmosomes between two Paget cells as well as between Paget cells and adjacent keratinocytes, occasionally giant mitochondria, abundance of cytoplasmic organelles, microvilli, and thick bundles of filaments not connected with plasma membrane. The keratinocytes frequently showed decreased numbers of desmosomes, moderate numbers of plasma membrane extensions resembling microvilli, rarefaction, and dispersion of tonofilament bundles, and an increase in cytoplasmic vesicles and ribosomes. The keratinocyte alterations and Paget cells ultrastructure suggest that Paget cells may originate from keratinocytes.