Three heroin addicts developed cutaneous necrotizing lesions at the sites of "skin popping." Investigation of the injected substances revealed that a quinine substitute which was being used to cut the heroin prior to street sale would produce similar lesions in the addicts when injected intracutaneously. Similar lesions were produced in mice after the first injection of this substance. The quinine substitute caused a nonspecific precipitate when combined with an addict's serum and the serum samples of three nonaddicted controls. These findings are compatible with the cutaneous lesions resulting from a direct toxic effect or primary irritant reaction of the quinine substitute in the skin. Black market methamphetamine hydrochloride did not produce similar lesions. Local and systemic reactions due to adulterants can be expected to be seen more frequently with the increasing heroin abuse.
Dunne JH, Johnson WC. Necrotizing Skin Lesions in Heroin Addicts. Arch Dermatol. 1972;105(4):544-547. doi:10.1001/archderm.1972.01620070016006