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Article
May 1972

Topical Therapy of Psoriasis With Mechlorethamine

Author Affiliations

Stanford, Calif

From the Department of Dermatology, Stanford (Calif) University School of Medicine. Dr. Zackheim is now with the University of California School of Medicine, San Francisco.

Arch Dermatol. 1972;105(5):702-706. doi:10.1001/archderm.1972.01620080032009
Abstract

Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%, and was highest with the 0.05% concentration. Occasional Koebner reactions and paradoxical results were noted. The high rate of sensitization precludes the use of this agent in the practical management of psoriasis.

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