The association of lymphedema to the appearance of xanthomas in a patient with primary lymphedema was investigated by employing a special staining procedure for iodized oil which revealed endogenous, rather than iodized fat in the xanthoma cells.
Berger BW, Kantor I, Maier HS. Xanthomatosis and Lymphedema. Arch Dermatol. 1972;105(5):730-733. doi:10.1001/archderm.1972.01620080056017