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Article
May 1972

NEW ENGLAND DERMATOLOGICAL SOCIETY

Arch Dermatol. 1972;105(5):767-774. doi:10.1001/archderm.1972.01620080085032
Abstract

Incontinentia Pigmenti. Presented by Richard L. Kidd, MD, and George F. Wilgram, MD.  A 17-year-old girl had a peculiar pattern of pigmentation during the first year of life. During a recent hospitalization, vesicles developed on her legs with subsequent papuleformation; the dermatitis spontaneously subsided over two- to four-week periods. The patient's teeth, eyes, and skeletal, central nervous, and cardiac systems were normal.Physical examination revealed increased pigmentation widely distributed from the neck to the ankles, taking the appearance of splashed paint and marble. The dermatitis is most striking over the back.

Discussion  Dr. Kidd: Dr. George F. Wilgram, Mr. Paul Cole, and I have had the opportunity to examine specimens of this girl's skin under the electron microscope. In addition to the pigmentary anomaly that we have reported elsewhere (to be published), the epidermis demonstrates a large number of Merkel cells in the basal layer. At least one Merkel cell

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